(19)
(11) EP 4 816 394 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24827387.2

(22) Date of filing: 22.11.2024
(51) International Patent Classification (IPC): 
C07K 16/10(2026.01)
A61P 31/16(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 2039/505; C07K 2317/76; C07K 2317/31; C07K 2317/92; A61P 31/16; C07K 16/108
(86) International application number:
PCT/US2024/057131
(87) International publication number:
WO 2025/117384 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 01.12.2023 US 202363605374 P

(71) Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
Bethesda, Maryland 20892-7788 (US)

(72) Inventors:
  • ANDREWS, Sarah Faith
    Bethesda, Maryland 20892 (US)
  • MANTUS, Grace Emma
    Bethesda, Maryland 20814 (US)
  • CHOPDE, Ankita Jayant
    Brookline, Massachusetts 02445 (US)
  • CREANGA, Adrian
    Bethesda, Maryland 20892 (US)
  • GILLESPIE, Rebecca Aileen
    Bethesda, Maryland 20892 (US)
  • KANEKIYO, Masaru
    Bethesda, Maryland 20892 (US)
  • COMINSKY, Lauren Yvette-Marie
    Philadelphia, Pennsylvania 19143 (US)
  • RAAB, Julie Eva
    Aurora, Colorado 80045 (US)

(74) Representative: Tombling, Adrian George 
Withers & Rogers LLP 2 London Bridge
London SE1 9RA
London SE1 9RA (GB)

   


(54) BROADLY NEUTRALIZING INFLUENZA HEMAGGLUTININ STEM-DIRECTED ANTIBODIES