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EP 4 816 395 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24896897.6 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07K 16/18(2006.01) G01N 33/53(2006.01) G01N 33/68(2006.01) A61P 31/12(2006.01) C07K 14/47(2006.01) G01N 33/577(2006.01) G01N 33/493(2006.01) A61P 31/04(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/04; A61P 31/12; C07K 14/47; G01N 33/493; G01N 33/56983; G01N 33/56911; G01N 2800/52; G01N 2333/4737; C07K 2317/34; C07K 16/12; C07K 16/08; C07K 2317/92 (86) International application number: PCT/IL2024/051120 (87) International publication number: WO 2025/115009 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 US 202363603181 P (71) Applicant: Accurine Ltd. 6350401 Tel Aviv (IL)	(72) Inventors: SHENHAR-TSARFATY, Shani 1515700 Kibbutz Gesher (IL) RIKLIN, Igal 4524706 Hod Hasharon (IL) LEVINSTEIN HALLAK, Keren 6937126 Tel Aviv (IL) ITAY, Peleg 1515700 Kibbutz Gesher (IL) SCHNEIDMAN, Yael 6473117 Tel Aviv (IL) (74) Representative: Kancelaria Eupatent.pl Sp. z o.o.  ul. Jana Kilinskiego 193 lok. 2.13 93-106 Lodz 93-106 Lodz (PL)