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EP 4 816 398 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24816921.1 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C07K 16/46(2006.01) A61P 37/06(2006.01) C07K 16/18(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2875; C07K 16/18; C07K 2317/622; C07K 2317/55; C07K 2317/76; A61K 2039/505; C07K 2317/24; C07K 2317/64; C07K 2319/31; A61P 37/06; C07K 14/70575 (86) International application number: PCT/EP2024/083686 (87) International publication number: WO 2025/114319 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 US 202363603406 P 01.05.2024 US 202463641087 P (71) Applicants: H. Lundbeck A/S 2500 Valby (DK) Aprilbio Co., Ltd Chuncheon-si, Gangwon-do 24341 (KR)

(72) Inventors: NOÉ, Francesco, Mattia 2500 Valby (DK) ASENJO MARTINEZ, Andrea 2500 Valby (DK) CHA, Sang, Hoon Chuncheon-si, Gangwon-do 24318 (KR) SONG, Moo, Young Suwon-si, Gyeonggi-do 16532 (KR) ELLIOT, Mark, Stephen, James 2500 Valby (DK) (74) Representative: H. Lundbeck A/S  Ottiliavej 9 2500 Valby 2500 Valby (DK)