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(11)

EP 4 816 403 A2

(12)

(88) Date of publication A3: 24.07.2025 (43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24828593.4 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2818; A61K 2039/545; A61K 2039/505; A61K 2039/507; A61K 2039/55; C07K 16/2803; A61N 2005/1098; A61K 39/39541; C07K 2317/21; A61P 35/00   C-Sets: A61K 39/39541, A61K 2300/00; (86) International application number: PCT/US2024/057962 (87) International publication number: WO 2025/117889 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604755 P (71) Applicant: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591 (US)	(72) Inventors: MILLER, Elizabeth Tarrytown, New York 10591 (US) LOWY, Israel Tarrytown, New York 10591 (US) MERAD, Miriam New York, New York 10029 (US) MARRON, Thomas New York, New York 10029 (US) SCHWARTZ, Myron New York, New York 10029 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)