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(11)

EP 4 816 405 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898563.2 (22) Date of filing: 25.11.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 47/68(2017.01) C07D 403/12(2006.01) C07K 16/32(2006.01) A61P 35/00(2006.01) C07D 491/22(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/30; C07K 16/2818; A61K 39/39541; A61K 2039/507; A61K 47/6857; A61K 47/6849; A61K 47/68035; A61K 47/6889   C-Sets: A61K 39/39541, A61K 2300/00; (86) International application number: PCT/US2024/057222 (87) International publication number: WO 2025/117403 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604592 P (71) Applicant: Merck Sharp & Dohme LLC Rahway, New Jersey 07065 (US)	(72) Inventors: LUBINIECKI, Gregory Michael Rahway, New Jersey 07065 (US) TABLANTE NUNES, Ana Rahway, New Jersey 07065 (US) (74) Representative: Merck Sharp & Dohme LLC  120 Moorgate London EC2M 6UR London EC2M 6UR (GB)