(19)

(11)

EP 4 816 406 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898606.9 (22) Date of filing: 25.11.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) C07K 16/32(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/244; C07K 2317/24; C07K 2317/92; C07K 2317/76; C07K 2317/31; C07K 2317/70; A61K 2039/507; A61K 2039/505 (86) International application number: PCT/US2024/057355 (87) International publication number: WO 2025/117485 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363604036 P (71) Applicant: Qilu Puget Sound Biotherapeutics Corporation Bothell, WA 98021 (US)	(72) Inventors: LIU, Zhi Bothell, WA 98021 (US) VISSINGA, Christine Bothell, WA 98021 (US) HAQUE, Jamil Bothell, WA 98021 (US) YAN, Wei Bothell, WA 98021 (US) (74) Representative: Keltie LLP  No. 1 London Bridge London SE1 9BA London SE1 9BA (GB)