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(11)

EP 4 816 407 A2

(12)

(88) Date of publication A3: 14.08.2025 (43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898630.9 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C07K 16/44(2006.01) C07K 16/18(2006.01) A61K 9/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/18; C07K 16/28 (86) International application number: PCT/US2024/057437 (87) International publication number: WO 2025/117530 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.11.2023 US 202363602923 P 14.05.2024 US 202463647206 P (71) Applicant: The Trustees of Columbia University in the City of New York New York, NY 10027 (US)

(72) Inventors: FITZPATRICK, Anthony, William, Paul New York, NY 10027 (US) YE, Junqiang New York, NY 10027 (US) BRENNER-MORTON, Susan, L. New York, NY 10027 (US) LEE, Carolyn New York, NY 10027 (US) (74) Representative: Berggren Oy  P.O. Box 16 Fabianinkatu 21 00101 Helsinki 00101 Helsinki (FI)