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EP 4 816 408 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898908.9 (22) Date of filing: 02.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/395(2006.01) C07K 16/24(2006.01) G01N 33/68(2006.01) A61P 37/04(2006.01) (52) Cooperative Patent Classification (CPC): A61P 37/04; G01N 33/68; C07K 16/2878; C07K 2317/76; C07K 2317/24; C07K 2317/71; C07K 2317/75; C07K 2317/74; C07K 2317/52; C07K 2317/35; G01N 2800/52; G01N 2333/70578 (86) International application number: PCT/US2024/058117 (87) International publication number: WO 2025/117965 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605306 P 17.07.2024 US 202463672340 P 28.08.2024 US 202463688121 P 28.08.2024 US 202418818268 (71) Applicant: The General Hospital Corporation Boston, MA 02114 (US)

(72) Inventor: FAUSTMAN, Denise, L. Boston, MA 02116 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)