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EP 4 816 409 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 25869411.6 (22) Date of filing: 19.09.2025

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/395(2006.01) A61P 37/04(2006.01) C07K 16/46(2006.01) A61K 39/00(2006.01) A61P 35/00(2006.01) C07K 16/22(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2818; C07K 2317/92; C07K 16/22; C07K 2317/31; C07K 2317/33; C07K 2317/76; C07K 2317/77; C07K 2317/94; A61K 2039/505 (86) International application number: PCT/US2025/047219 (87) International publication number: WO 2026/064650 (26.03.2026 Gazette 2026/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH LA MA MD TN (30) Priority: 20.09.2024 US 202463697436 P 13.11.2024 US 202463719870 P 14.04.2025 US 202563788196 P 26.06.2025 US 202563831020 P (71) Applicant: PARAGON THERAPEUTICS, INC. Waltham, MA 02453 (US)

(72) Inventors: KANG, Byong Ha Waltham, Massachusetts 02453 (US) SHAHEEN, Hussam Hisham Waltham, Massachusetts 02453 (US) RAGHUNATHAN, Gopalan Waltham, Massachusetts 02453 (US) FAYAD, Ghassan Najib Waltham, Massachusetts 02453 (US) ALAM, Mohammad Murshid Waltham, Massachusetts 02453 (US) (74) Representative: Heath, Abigail et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)