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(11)

EP 4 816 412 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898840.4 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C07K 16/32(2006.01) A61P 35/00(2006.01) C07K 16/46(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/32; A61P 35/00; C07K 2317/31; C07K 2317/35; C07K 2317/622; C07K 2317/55; C07K 2317/73; C07K 2317/92 (86) International application number: PCT/US2024/057935 (87) International publication number: WO 2025/117871 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363604087 P (71) Applicant: SystImmune, Inc. Redmond WA 98052 (US)	(72) Inventors: RENSHAW, Blair Renton, Washington 98058 (US) ZHU, Yi Redmond, Washington 98052 (US) (74) Representative: Mathys & Squire  32 London Bridge Street The Shard London SE1 9SG London SE1 9SG (GB)