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EP 4 816 414 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 23959739.6 (22) Date of filing: 28.11.2023

(51) International Patent Classification (IPC):  C07K 19/00(2006.01) C12N 15/63(2006.01) A61P 35/00(2006.01) A61P 29/00(2006.01) A61K 39/395(2006.01) C12N 15/11(2006.01) A61P 27/02(2006.01) A61P 17/06(2006.01) A61P 9/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/00; A61P 17/06; A61P 27/02; A61P 29/00; A61P 35/00; C07K 16/28; A61K 2039/505; C07K 2319/30; C07K 2317/76; C07K 2319/00; C07K 14/71 (86) International application number: PCT/CN2023/134829 (87) International publication number: WO 2025/111816 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: SHEN, Wei Yong Beijing 100005 (CN) ZHANG, Jinzhong Beijing 100005 (CN) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)