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EP 4 816 479 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898397.5 (22) Date of filing: 17.04.2024

(51) International Patent Classification (IPC):  C09B 69/10(2006.01) C09B 11/08(2006.01) A61K 49/00(2006.01) C09K 11/07(2006.01) (52) Cooperative Patent Classification (CPC): C09K 11/06; C09K 2211/188; C09K 2211/1466; C09B 69/108; A61K 49/0002; A61K 49/128; A61K 49/085; A61K 49/221; A61K 41/0057; A61K 47/64; A61K 47/56; A61K 49/0021; A61K 49/0054; A61K 49/0056; A61K 49/124; A61K 49/0058; A61K 49/16 (86) International application number: PCT/US2024/024926 (87) International publication number: WO 2025/116953 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604557 P (71) Applicants: North Carolina State University Raleigh, North Carolina 27606 (US) Nirvana Sciences Research Triangle Park, NC 27709 (US)

(72) Inventors: LINDSEY, Jonathan S. Raleigh, North Carolina 27608 (US) THOMAS, Russell D. Wake Forest, North Carolina 27587 (US) AKHIGBE, Joshua Durham, North Carolina 27707 (US) MACNEVIN, Christopher Durham, North Carolina 27713 (US) STOYCHEV, Georgi V. Ames, Iowa 50010 (US) OLSZEWSKI, Mateusz Durham, North Carolina (US) YANG, Su Cary, North Carolina 27519 (US) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)