(19)

(11)

EP 4 816 518 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24817745.3 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  C12N 5/00(2006.01) C12Q 1/6816(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6816; C12N 5/0068; C12N 2533/00   C-Sets: C12Q 1/6816, C12Q 2525/101; (86) International application number: PCT/NL2024/050641 (87) International publication number: WO 2025/116732 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 EP 23213639 (71) Applicant: RIJKSUNIVERSITEIT GRONINGEN 9712 CP Groningen (NL)	(72) Inventors: VAN DEN BOGAART, Geert 9712 CP Groningen (NL) BIANCHI, Frans 9712 CP Groningen (NL) FRANS, Myrthe Tiara 9712 CP Groningen (NL) (74) Representative: V.O.  P.O. Box 87930 2508 DH Den Haag 2508 DH Den Haag (NL)