(19)
(11) EP 4 816 521 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24821701.0

(22) Date of filing: 21.11.2024
(51) International Patent Classification (IPC): 
C12N 5/071(2010.01)
(52) Cooperative Patent Classification (CPC):
C12N 5/0676; C12N 2500/34; C12N 5/0678; C12N 2506/02
(86) International application number:
PCT/US2024/056908
(87) International publication number:
WO 2025/117331 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 01.12.2023 US 202363605259 P

(71) Applicant: Sigilon Therapeutics, Inc.
Indianapolis, Indiana 46285 (US)

(72) Inventors:
  • BANDUKWALA, Hozefa
    Indianapolis, Indiana 46206-6288 (US)
  • EFANOV, Alexander
    Indianapolis, Indiana 46206-6288 (US)
  • IVASHCHENKO, Christine
    Indianapolis, Indiana 46206-6288 (US)
  • JING, Enxuan
    Indianapolis, Indiana 46206-6288 (US)
  • JING, Ying
    Indianapolis, Indiana 46206-6288 (US)
  • KELLY, Olivia
    Indianapolis, Indiana 46206-6288 (US)
  • LAMBALOT, Matthew T.
    Indianapolis, Indiana 46206-6288 (US)
  • LAWSON, Tristan Fabian Samuel
    Indianapolis, Indiana 46206-6288 (US)
  • MCCLATCHEY, JR., Penn Mason
    Indianapolis, Indiana 46206-6288 (US)
  • MOZDZIERZ, Nicholas Joseph
    Indianapolis, Indiana 46206-6288 (US)
  • SHI, Xiaoying
    Indianapolis, Indiana 46206-6288 (US)
  • THOMAS, Melissa
    Indianapolis, Indiana 46206-6288 (US)

(74) Representative: Eli Lilly and Company Limited 
8 Arlington Square West Downshire Way
Bracknell, Berkshire RG12 1PU
Bracknell, Berkshire RG12 1PU (GB)

   


(54) METHODS OF MAKING STEM CELL-DERIVED ISLET-LIKE CELLS, AS WELL AS POPULATIONS AND COMPOSITIONS INCLUDING THE SAME