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(11)

EP 4 816 522 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24895253.3 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  C12N 5/071(2010.01) C12N 5/00(2006.01) A61K 35/39(2015.01) G01N 33/50(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/39; C12N 5/0676; C12N 2501/115; C12N 2501/727; C12N 2501/16; C12N 2501/415; C12N 2501/119; C12N 2501/155; C12N 2501/385; C12N 2501/11; C12N 2506/02; C12N 2506/45 (86) International application number: PCT/CA2024/051410 (87) International publication number: WO 2025/111693 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604826 P (71) Applicant: University Health Network Toronto, Ontario M5G 2C4 (CA)	(72) Inventors: MCGAUGH, Emily Catherine Brampton, Ontario L6Z 2W6 (CA) NOSTRO, Maria Cristina Toronto, Ontario M5J 2Z7 (CA) MISRA, Paraish Shivam Toronto, Ontario M4N 0A4 (CA) (74) Representative: AWA Sweden AB  Box 5117 200 71 Malmö 200 71 Malmö (SE)