(19)
(11) EP 4 816 525 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24898598.8

(22) Date of filing: 25.11.2024
(51) International Patent Classification (IPC): 
C12N 5/077(2010.01)
A61K 35/545(2015.01)
C12N 5/0786(2010.01)
C12N 5/00(2006.01)
 A61K 35/34(2015.01)
C12N 5/02(2006.01)
A61P 9/10(2006.01)
C12N 5/074(2010.01)
(52) Cooperative Patent Classification (CPC):
A61K 35/34; A61P 9/10; C12N 5/0657; C12N 2506/45; C12N 2506/02; C12N 2501/415; C12N 2500/16; C12N 2500/10; C12N 2500/25; C12N 2501/15; C12N 2501/115; C12N 2501/727
(86) International application number:
PCT/US2024/057335
(87) International publication number:
WO 2025/117472 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 30.11.2023 US 202363604867 P

(71) Applicant: Immorta Bio, Inc.
Miami Beach, FL 33109 (US)

(72) Inventors:
  • ICHIM, Thomas E.
    Miami Beach, Florida 33109 (US)
  • REZNIK, Boris
    Miami Beach, Florida 33109 (US)
  • REZNIK, Gary
    Miami Beach, Florida 33109 (US)
  • KAPLUN, Yuri
    Miami Beach, Florida 33109 (US)

(74) Representative: Michalski Hüttermann & Partner mbB 
Kaistraße 16A
40221 Düsseldorf
40221 Düsseldorf (DE)

   


(54) TREATMENT OF HEART FAILURE USING PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES AND DERIVATIVES THEREOF