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EP 4 816 526 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24895271.5 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) C07K 17/10(2006.01) C08J 3/075(2006.01) C12N 5/00(2006.01) C07K 17/08(2006.01) C08J 3/24(2006.01) C08J 7/12(2006.01) (52) Cooperative Patent Classification (CPC): C08J 3/075; C07K 17/10; C08J 3/246; C08J 2305/08; C08J 2405/08; C08J 2389/00; C08J 2489/00; C08J 2371/02; C08J 2471/02; C12N 2513/00; C12N 2533/80; C12N 2501/125; C12N 2501/2307; C12N 2501/145; C12N 2501/26; C12N 2506/45; C12N 2501/727; C12N 2501/155; C12N 2501/415; C12N 2501/11; C12N 2501/2306; C12N 2501/2311; C12N 2501/14; C12N 2501/105; C12N 5/0636; C12N 5/0647; C12N 2506/11; C12N 2500/24; C12N 2501/165; C12N 2501/2303; C12N 2537/10; C12N 2533/54; C07K 2319/30; C07K 14/435 (86) International application number: PCT/CA2024/051591 (87) International publication number: WO 2025/111711 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 US 202363603323 P (71) Applicants: The University of British Columbia Vancouver, British Columbia V6T 1Z3 (CA) The Governing Council of the University of Toronto Toronto, Ontario M5G 0C6 (CA)

(72) Inventors: ZANDSTRA, Peter Vancouver, British Columbia V6R 3M8 (CA) PRIMBETOVA, Asel Vancouver, British Columbia V6R 1R4 (CA) BAKER, Alexander Timberlea, Nova Scotia B3T 1J7 (CA) SHOICHET, Molly York, Ontario M6C 1M6 (CA) (74) Representative: Synergy IP Group AG  Unterer Rheinweg 50 Postfach 4001 Basel 4001 Basel (CH)