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(11)

EP 4 816 528 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24896706.9 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  C12N 9/12(2006.01) C12P 19/34(2006.01) C12N 15/54(2006.01) (52) Cooperative Patent Classification (CPC): C12P 19/34; C12N 15/70; C12N 9/1247; C12Y 207/07006 (86) International application number: PCT/CN2024/135591 (87) International publication number: WO 2025/113623 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 CN 202311611155 (71) Applicant: RNASYN Biotech. Co., Ltd. Wuhan, Hubei 430075 (CN)	(72) Inventors: ZHU, Bin Wuhan, Hubei 430074 (CN) YU, Bingbing Wuhan, Hubei 430075 (CN) CHEN, Yifan Wuhan, Hubei 430075 (CN) (74) Representative: Secerna LLP  The Old Fire Station 18 Clifford Street York YO1 9RD York YO1 9RD (GB)