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(11)

EP 4 816 529 A2

(12)

(88) Date of publication A3: 31.07.2025 (43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898839.6 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) C07K 14/47(2006.01) C12N 15/85(2006.01) A61P 35/00(2006.01) C12N 15/63(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2310/20; C12N 15/113; C12N 9/226; C12N 2320/10 (86) International application number: PCT/US2024/057925 (87) International publication number: WO 2025/117868 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.11.2023 US 202363602887 P (71) Applicant: Duke University Durham, NC 27705 (US)	(72) Inventors: GERSBACH, Charles Chapel Hill, North Carolina 27516 (US) HOFFMAN, Brenton Durham, North Carolina 27705 (US) CRAWFORD, Gregory Durham, North Carolina 27705 (US) COSGROVE, Brian Durham, North Carolina 27705 (US) (74) Representative: Harris, Oliver John Richard  Novagraaf UK Centrum Norwich Research Park Colney Lane Norwich NR4 7UG Norwich NR4 7UG (GB)