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(11)

EP 4 816 531 A2

(12)

(88) Date of publication A3: 10.07.2025 (43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24828248.5 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  C12N 15/10(2006.01) C12N 15/63(2006.01) C12N 9/22(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12N 15/102; C12N 2310/20; C12N 15/63; C12N 9/226 (86) International application number: PCT/US2024/057946 (87) International publication number: WO 2025/117877 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363604978 P (71) Applicant: Flagship Pioneering Innovations VII, LLC Cambridge, MA 02142 (US)	(72) Inventors: TIAN, Pengfei Cambridge, Massachusetts 02142 (US) SORENSEN, Trine Holst Cambridge, Massachusetts 02142 (US) JONES, Stephen Merritt Cambridge, Massachusetts 02142 (US) OKAFOR, Ikenna Christopher Cambridge, Massachusetts 02142 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)