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EP 4 816 532 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24820279.8 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) C12P 19/34(2006.01) C12N 15/66(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/111; C12N 2310/20; C12N 2330/30; C12P 19/34; C12N 15/66 (86) International application number: PCT/EP2024/083922 (87) International publication number: WO 2025/114441 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 EP 23213347 (71) Applicants: F. Hoffmann-La Roche AG 4070 Basel (CH) GENENTECH, INC. South San Francisco, CA 94080 (US)

(72) Inventors: BIGATTI, Martina 4070 Basel (CH) BISAGNI, Serena 4070 Basel (CH) COVATO, Elena 4070 Basel (CH) FANTONI ZUIN, Nicolo 4070 Basel (CH) HANLON, Steven Paul 4070 Basel (CH) KOENIG, Stefan G. South San Francisco, California 94080 (US) SLADOJEVICH, Filippo 4070 Basel (CH) (74) Representative: Küng, Peter  F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)