(19)

(11)

EP 4 816 535 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898636.6 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) C12P 19/34(2006.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): C12N 15/117; C12N 2310/17; C12N 2310/51 (86) International application number: PCT/US2024/057453 (87) International publication number: WO 2025/117540 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604458 P (71) Applicant: The Regents of the University of Michigan Ann Arbor, Michigan 48109-2590 (US)	(72) Inventors: WU, Connie Ann Arbor, Michigan 48109-2590 (US) YANG, Yinying Ann Arbor, Michigan 48109-2590 (US) ALVAREZ, Andrew Ann Arbor, Michigan 48109-2590 (US) (74) Representative: Algemeen Octrooi- en Merkenbureau B.V.  P.O. Box 645 5600 AP Eindhoven 5600 AP Eindhoven (NL)