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EP 4 816 536 A2

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(88) Date of publication A3: 10.07.2025 (43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24834132.3 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/713(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2310/14; A61K 31/713; C12N 2320/11; C12N 2310/315; C12N 2310/351; C12N 2320/32; C12N 15/1137; C12Y 304/21007   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/US2024/057703 (87) International publication number: WO 2025/117709 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 WO PCT/CN2023/135082 (71) Applicant: Sanegene Bio USA Inc. Woburn, Massachusetts 01801 (US)	(72) Inventors: ZHOU, Chunxue Suzhou, Jiangsu 215103 (CN) ZHANG, Chunyang Woburn, Massachusetts 01801 (US) WANG, Shiyu Woburn, Massachusetts 01801 (US) WANG, Weimin Woburn, Massachusetts 01801 (US) (74) Representative: Barrow, Nicholas Martin  Venner Shipley LLP 406 Cambridge Science Park Milton Road Cambridge CB4 0WW Cambridge CB4 0WW (GB)