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EP 4 816 539 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24895232.7 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  C12N 15/82(2006.01) C07K 14/415(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/8213; C12N 15/8282; C12N 15/8205; C07K 14/415; C12N 15/8202 (86) International application number: PCT/AU2024/051287 (87) International publication number: WO 2025/111663 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 AU 2023903851 (71) Applicant: Commonwealth Scientific and Industrial Research Organisation Acton, Australian Capital Territory 2601 (AU)

(72) Inventors: LUO, Ming Acton, Australian Capital Territory 2601 (AU) AYLIFFE, Michael Acton, Australian Capital Territory 2601 (AU) CHEN, Jian Acton, Australian Capital Territory 2601 (AU) BHATT, Dhara Acton, Australian Capital Territory 2601 (AU) BROOKS, Brenton Acton, Australian Capital Territory 2601 (AU) WANG, Aihua Acton, Australian Capital Territory 2601 (AU) (74) Representative: Ernest Gutmann - Yves Plasseraud S.A.S.  c/o Plasseraud IP CS92104 104 Rue de Richelieu 75080 Paris Cedex 02 75080 Paris Cedex 02 (FR)