(19)
(11) EP 4 816 541 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24827995.2

(22) Date of filing: 27.11.2024
(51) International Patent Classification (IPC): 
C12N 15/90(2006.01)
 C12N 15/63(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/907; C12N 2750/14143; C12N 2310/20; C12N 15/102; C12N 2830/48; C12N 2800/30; C12N 15/86; C12N 15/113; C07K 14/705
(86) International application number:
PCT/US2024/057757
(87) International publication number:
WO 2025/117745 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 01.12.2023 US 202363605082 P
26.09.2024 US 202463699524 P

(71) Applicant: Caribou Biosciences, Inc.
Berkeley, CA 94710 (US)

(72) Inventors:
  • DONOHOUE, Paul D.
    Berkeley, CA 94710 (US)
  • GRADIA, Scott D.
    Berkeley, CA 94710 (US)

(74) Representative: Grund, Martin et al
Grund Intellectual Property Group Patentanwälte und Solicitor PartG mbB Steinsdorfstraße 2
80538 München
80538 München (DE)

   


(54) METHODS AND COMPOSITIONS FOR IMPROVING PRECISION OF ENDONUCLEASE-MEDIATED GENOME EDITING