(19)
(11) EP 4 816 542 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24898863.6

(22) Date of filing: 29.11.2024
(51) International Patent Classification (IPC): 
C12N 15/90(2006.01)
C12N 9/22(2006.01)
C07K 14/78(2006.01)
 C07K 7/06(2006.01)
C12N 15/10(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 14/78; C07K 7/06; C12N 15/90; C12N 9/22; C12N 15/87; C12N 15/102; C07K 2319/00; C07K 2319/02; C07K 2319/09; C07K 2319/10; A61P 35/00
(86) International application number:
PCT/US2024/057977
(87) International publication number:
WO 2025/117903 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 29.11.2023 US 202363603930 P
23.09.2024 US 202463697761 P

(71) Applicant: Ohio State Innovation Foundation
Columbus OH 43210 (US)

(72) Inventors:
  • PEI, Dehua
    Columbus, Ohio 43210 (US)
  • BHAT, Prabhat
    Columbus, Ohio 43210 (US)

(74) Representative: Berggren Oy 
P.O. Box 16 Fabianinkatu 21
00101 Helsinki
00101 Helsinki (FI)

   


(54) INTRACELLULAR DELIVERY OF GENE-EDITING ENZYMES AND USES THEREOF