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EP 4 816 545 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898604.4 (22) Date of filing: 25.11.2024

(51) International Patent Classification (IPC):  C12Q 1/68(2018.01) G06F 18/22(2023.01) G16H 50/70(2018.01) A61P 35/02(2006.01) A61K 31/33(2006.01) G16H 20/10(2018.01) G16H 70/40(2018.01) A61P 43/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/02; A61P 43/00; G06F 18/22; G16H 20/10; G16H 50/70; G16H 70/40; G16H 40/63; G06F 18/217 (86) International application number: PCT/US2024/057349 (87) International publication number: WO 2025/117480 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363603785 P (71) Applicants: Memorial Sloan-Kettering Cancer Center New York, NY 10065 (US) Memorial Hospital for Cancer and Allied Diseases New York, NY 10065 (US) Sloan-kettering Institute For Cancer Research New York, NY 10065 (US)

(72) Inventors: TANSEY, Wesley New York, New York 10065 (US) TOSH, Christopher New York, New York 10065 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)