(19)
(11) EP 4 816 549 A2

(12)

(88) Date of publication A3:
10.07.2025

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24898744.8

(22) Date of filing: 27.11.2024
(51) International Patent Classification (IPC): 
C12Q 1/6809(2018.01)
C12Q 1/6869(2018.01)
C12Q 1/6886(2018.01)
 C12N 15/10(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
C12Q 1/6886; C12Q 2600/156
(86) International application number:
PCT/US2024/057702
(87) International publication number:
WO 2025/117708 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 28.11.2023 US 202363603471 P

(71) Applicant: Baruch S. Blumberg Institute
Doylestown, PA 18902 (US)

(72) Inventors:
  • BLOCK, Timothy M.
    Doylestown, Pennsylvania 18901 (US)
  • ZEZULINSKI, Daniel
    Philadelphia, Pennsylvania 19127 (US)
  • SHEIKH, Aejaz Sayeed
    Downington, Pennsylvania 19335 (US)

(74) Representative: Studio Torta S.p.A. 
Via Viotti, 9
10121 Torino
10121 Torino (IT)

   


(54) METHOD AND SYSTEM FOR USE OF MUTANT MRNA IN LIQUID BIOPSIES TO RISK STRATIFY AND MANAGE CANCER