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EP 4 816 557 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24896846.3 (22) Date of filing: 21.11.2024

(51) International Patent Classification (IPC):  C12Q 1/6883(2018.01) G16H 50/20(2018.01) G16B 40/20(2019.01) G06N 20/10(2019.01) (52) Cooperative Patent Classification (CPC): G16H 50/20; G16B 40/20; G06N 20/10; G16H 50/30; G16H 50/70; G16H 40/67; G16H 20/10; G16H 20/40; C12Q 1/6886; C12Q 2600/156 (86) International application number: PCT/IB2024/061672 (87) International publication number: WO 2025/114824 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 US 202363603240 P (71) Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION Pittsburgh, Pennsylvania 15260 (US)	(72) Inventors: LUO, Jianhua Pittsburgh, Pennsylvania 15260 (US) GELLER, David, A. Pittsburgh, Pennsylvania 15260 (US) LIU, Shuchang Pittsburgh, Pennsylvania 15260 (US) YU, Yanping Pittsburgh, Pennsylvania 15260 (US) (74) Representative: Kraus & Lederer PartGmbB  Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)