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EP 4 816 946 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24827383.1 (22) Date of filing: 22.11.2024

(51) International Patent Classification (IPC):  G06F 16/84(2019.01) G06F 16/9032(2019.01) (52) Cooperative Patent Classification (CPC): G06F 16/84; G06F 16/90332 (86) International application number: PCT/US2024/057117 (87) International publication number: WO 2025/117380 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605066 P (71) Applicants: Genentech Inc. South San Francisco, California 94080-4990 (US) F. Hoffmann-La Roche AG 4070 Basel (CH)

(72) Inventors: PANDIT, Yogesh P. San Francisco, California 94080 (US) SETT, Arindam San Francisco, California 94080 (US) HASHEMIFAR, Somaye Sadat San Francisco, California 94080 (US) HEJRATI, Seyed Mohammadmohsen San Francisco, California 94080 (US) YADAV, Mrunal Shriram San Francisco, California 94080 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)