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EP 4 823 554 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24833520.0 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  A61K 9/51(2006.01) A61P 11/12(2006.01) A61P 11/00(2006.01) A61K 47/18(2017.01) (52) Cooperative Patent Classification (CPC): A61K 9/5123; A61K 47/18; A61P 11/00; A61P 11/12 (86) International application number: PCT/EP2024/086394 (87) International publication number: WO 2025/132122 (26.06.2025 Gazette 2025/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609584 P (71) Applicants: Charité Universitätsmedizin Berlin - Körperschaft des öffentlichen Rechts 10117 Berlin (DE) Acuitas Therapeutics, Inc. Vancouver, British Columbia V6T 1Z3 (CA)

(72) Inventors: SUNG, Molly M. H. Vancouver, British Columbia V6T 1Z3 (CA) LIN, Paulo Jia Ching Vancouver, British Columbia V6T 1Z3 (CA) TAM, Ying K. Vancouver, British Columbia V6T 1Z3 (CA) HEDTRICH, Sarah 10178 Berlin (DE) (74) Representative: Michalski Hüttermann & Partner mbB  Kaistraße 16A 40221 Düsseldorf 40221 Düsseldorf (DE)