(19)
(11) EP 4 823 555 A2

(12)

(88) Date of publication A3:
24.07.2025

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24838128.7

(22) Date of filing: 12.12.2024
(51) International Patent Classification (IPC): 
A61K 9/51(2006.01)
C07C 225/20(2006.01)
C07C 323/60(2006.01)
 C07C 219/10(2006.01)
C07C 229/12(2006.01)
C07D 471/08(2006.01)
(52) Cooperative Patent Classification (CPC):
C07C 2603/74; C07C 229/12; C07B 2200/05; C07C 323/60; C07C 219/10; C07C 2601/04; C07C 225/20; C07C 2603/90; C07C 2602/44; A61K 9/5123; C07D 453/02; C07D 493/06; C07D 453/06; C07D 221/04; C07D 491/22; C07D 221/22; C07D 311/00; A61K 31/7105
(86) International application number:
PCT/US2024/059846
(87) International publication number:
WO 2025/128871 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 13.12.2023 US 202363609553 P
30.01.2024 US 202463626846 P
06.03.2024 US 202463562084 P
19.03.2024 US 202463567152 P
26.03.2024 US 202463570024 P
22.04.2024 US 202463637221 P
29.04.2024 US 202463639863 P
15.07.2024 US 202463671415 P

(71) Applicants:
  • Renagade Therapeutics Management Inc.
    Watertown, MA 02472 (US)
  • Orna Therapeutics, Inc.
    Watertown, MA 02472 (US)

(72) Inventors:
  • JAYARAMAN, Muthusamy
    Watertown, Massachusetts 02472 (US)
  • SANKARAN, Ganapathy Subramanian
    Watertown, Massachusetts 02472 (US)
  • SMITH, David Townsend
    Watertown, Massachusetts 02472 (US)
  • RHYM, Luke Hyunsik
    Watertown, Massachusetts 02472 (US)
  • NARAYANAN, Elisabeth
    Watertown, Massachusetts 02472 (US)
  • JOHN, Shinu
    Watertown, Massachusetts 02472 (US)
  • WANG, Yinghua
    Watertown, Massachusetts 02472 (US)
  • KOSAKOWSKA, Karolina Anna
    Watertown, Massachusetts 02472 (US)
  • BOLEN, Joseph
    Watertown, Massachusetts 02472 (US)
  • PRESNYAK, Vladimir
    Watertown, Massachusetts 02472 (US)
  • PEPIN, Christopher Stephen
    Watertown, Massachusetts 02472 (US)

(74) Representative: Goodwin Procter (UK) LLP 
Sancroft, 10-15 Newgate Street
EC1A 7AZ / London
EC1A 7AZ / London (GB)

   


(54) LIPID NANOPARTICLES COMPRISING CODING RNA MOLECULES FOR USE IN GENE EDITING AND AS VACCINES AND THERAPEUTIC AGENTS