(19)

(11)

EP 4 823 556 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24841536.6 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  A61K 9/51(2006.01) A61K 47/12(2006.01) C12N 15/88(2006.01) A61K 31/713(2006.01) A61K 47/18(2017.01) (52) Cooperative Patent Classification (CPC): A61K 9/5123; A61K 47/12; A61K 47/183; A61K 9/0019; C12N 15/88; A61K 31/713; A61K 31/7105 (86) International application number: PCT/US2024/059975 (87) International publication number: WO 2025/128958 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363611075 P (71) Applicant: ELI LILLY AND CO. Indianapolis, IN 46285 (US)	(72) Inventors: ESTABROOK, Daniel Indianapolis, IN 46285 (US) YU, Zhao Indianapolis, IN 46285 (US) HUANG, Lihua Indianapolis, IN 46285 (US) WANG, Tingting Indianapolis, Indiana 46285 (US) LUCCHESE, Olivia Rose Indianapolis, IN 46285 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)