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(11)

EP 4 823 566 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904925.5 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/4192(2006.01) A61K 31/33(2006.01) A61K 31/44(2006.01) A61K 9/14(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/5123; A61K 9/0019; A61K 31/19; A61K 31/7016; A61K 45/06; A61K 38/16; A61K 38/07 (86) International application number: PCT/US2024/059909 (87) International publication number: WO 2025/128913 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363609213 P 05.04.2024 US 202463575363 P 12.09.2024 US 202463693792 P (71) Applicant: The Trustees of The University of Pennsylvania Philadelphia, PA 19104 (US)

(72) Inventors: BRENNER, Jacob Princeton Junction, New Jersey 08550 (US) OMO-LAMAI, Serena Philadelphia, Pennsylvania 19104 (US) WANG, Yufei Philadelphia, Pennsylvania 19104 (US) PATEL, Manthan Fairless Hills, Pennsylvania 19030 (US) ESPY, Carolann Philadelphia, Pennsylvania 19103 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)