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(11)

EP 4 823 574 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904820.8 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  A61K 31/439(2006.01) A61K 9/20(2006.01) A61P 25/34(2006.01) A61K 31/465(2006.01) A24B 15/16(2020.01) A61K 9/48(2006.01) C07D 471/18(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/198; A61K 31/439; A61K 33/00; A61K 9/2013 (86) International application number: PCT/US2024/059604 (87) International publication number: WO 2025/128723 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363608959 P (71) Applicant: Achieve Life Sciences, Inc. Bothell, WA 98021 (US)	(72) Inventors: DELGADO RUEDA, Marco Antonio Peter Bucks Buckinghamshire SL90DS (GB) MILLER, Kelly Bothell, Washington 98021 (US) DONNELLY, Craig Bothell, Washington 98021 (US) ELDER, David Stevenage Hertfordshire SG1 2FX (GB) SEARLE, Andrew Stevenage Hertfordshire SG1 2FX (GB) (74) Representative: Mathys & Squire  32 London Bridge Street The Shard London SE1 9SG London SE1 9SG (GB)