(19)
(11) EP 4 823 577 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24902970.3

(22) Date of filing: 13.12.2024
(51) International Patent Classification (IPC): 
A61K 31/4745(2006.01)
C07K 16/00(2006.01)
A61K 39/395(2006.01)
A61P 31/00(2006.01)
 A61K 31/47(2006.01)
C07D 491/22(2006.01)
A61K 47/68(2017.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 31/00; A61P 35/00; C07D 491/22; A61K 47/68037; A61K 47/6889; A61K 47/6855; C07D 495/22; C07D 513/22
(86) International application number:
PCT/CN2024/139197
(87) International publication number:
WO 2025/124555 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 14.12.2023 WO PCT/CN2023/138628
13.09.2024 WO PCT/CN2024/118834

(71) Applicant: Shanghai MicuRx Pharmaceutical Co., Ltd.
Shanghai 201203 (CN)

(72) Inventors:
  • YANG, Hongyu
    Shanghai 201203 (CN)
  • WANG, Xinghai
    Shanghai 201203 (CN)

(74) Representative: Crow, Martin 
Venner Shipley LLP TIDE Bankside 8 Emerson Street
London SE1 9DU
London SE1 9DU (GB)

   


(54) LIGAND-DRUG CONJUGATE OF CAMPTOTHECIN ANALOGS AND USE THEREOF