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EP 4 823 578 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904745.7 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  A61K 31/48(2006.01) A61K 9/20(2006.01) A61K 9/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/38; A61P 25/00; A61K 9/0056; A61K 9/2059; A61K 9/2054; A61K 9/2018; A61K 9/1623 (86) International application number: PCT/US2024/059413 (87) International publication number: WO 2025/128594 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608396 P 11.12.2023 US 202363608486 P (71) Applicant: Definium Therapeutics US, Inc. New York, NY 10007 (US)	(72) Inventors: BARROW, Robert Madison, Wisconsin 53703 (US) KARLIN, Daniel R. New York, New York 10013 (US) MACK, Peter Chapel Hill, North Carolina 27516 (US) SRINIVAS, Nithya Weehawken, New Jersey 07086 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)