(19)

(11)

EP 4 823 585 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24828786.4 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  A61K 31/7088(2006.01) C12N 15/113(2010.01) A61K 31/713(2006.01) C12Q 1/6883(2018.01) (52) Cooperative Patent Classification (CPC): C12N 2310/11; C12Q 1/6883; A61K 31/713; C12N 15/1137; C12N 2310/341; C12N 2310/3231; C12N 2310/315 (86) International application number: PCT/EP2024/086162 (87) International publication number: WO 2025/125542 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 EP 23217073 (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: DAETWYLER, Philipp 4070 Basel (CH) SCHWAB, Dietmar 4070 Basel (CH) (74) Representative: Rodriguez Novoa, Lorena  F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)