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(11)

EP 4 823 587 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24827067.0 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 35/28(2015.01) A61P 1/02(2006.01) A61L 31/14(2006.01) A61K 45/06(2006.01) A61L 26/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 1/02; A61K 35/28; A61K 45/06; C12N 5/0668; C12N 2501/11; C12N 2501/39; C12N 2501/33 (86) International application number: PCT/EP2024/085951 (87) International publication number: WO 2025/125449 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 EP 23383285 (71) Applicant: Gistem Research S.L. 33204 Gijón Asturias (ES)	(72) Inventors: VIZOSO PIÑEIRO, Francisco José 33204 Gijón (Asturias) (ES) COSTA PÉREZ, Luis Alberto 33204 Gijón (Asturias) (ES) EIRÓ DÍAZ, Noemí 33204 Gijón (Asturias) (ES) (74) Representative: Hoffmann Eitle  Hoffmann Eitle S.L.U. Calle Nuñez de Balboa 120 6 Izquierdo 28006 Madrid 28006 Madrid (ES)