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EP 4 823 588 A2

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(88) Date of publication A3: 17.07.2025 (43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904810.9 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  A61K 35/747(2015.01) A61Q 17/04(2006.01) C12R 1/25(2006.01) A61L 26/00(2006.01) A61Q 19/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/747; A61K 9/06; A61K 8/99; A61Q 19/00; A61K 9/0014; A61K 47/38; A61L 26/0057; A61L 26/0023; A61L 26/008   C-Sets: A61L 26/0023, C08L 1/04; (86) International application number: PCT/US2024/059584 (87) International publication number: WO 2025/128710 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608636 P (71) Applicant: University of South Florida Tampa, FL 33612 (US)	(72) Inventors: YADAV, Hariom Tampa, Florida 33612 (US) JAIN, Shalini Tampa, Florida 33612 (US) PRAJAPATI, Santosh, K. Tampa, Florida 33612 (US) CHANDER, Atul, Munish Tampa, Florida 33612 (US) (74) Representative: Dehns  10 Old Bailey London EC4M 7NG London EC4M 7NG (GB)