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EP 4 823 589 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24829466.2 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  A61K 35/76(2015.01) C07K 14/005(2006.01) C12N 15/86(2006.01) A61K 48/00(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C07K 14/005; C12N 15/907; C12N 2750/14143; C12N 2750/14145; C12N 2750/14122; A61K 48/0041; C12N 2510/00; C12N 5/0653; C12N 2501/33; C12N 2501/392 (86) International application number: PCT/EP2024/086667 (87) International publication number: WO 2025/125692 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 EP 23216890 (71) Applicants: Medizinische Hochschule Hannover 30625 Hannover (DE) Syddansk Universitet 5230 Odense M (DK)	(72) Inventors: BÜNING, Hildegard 30625 Hannover (DE) KORNFELD, Jan-Wilhelm 5230 Odense M (DK) JÄSCHKE, Nico 30625 Hannover (DE) RUPPERT, Philip 5230 Odense M (DK) PRADAS-JUNI, Marta 5230 Odense M (DK) GÜLLER, Aylin Seren 5230 Odense M (DK) (74) Representative: Taruttis, Stefan Georg  TARUTTIS Patentanwaltskanzlei Aegidientorplatz 2b 30159 Hannover 30159 Hannover (DE)