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EP 4 823 594 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904507.1 (22) Date of filing: 09.12.2024

(51) International Patent Classification (IPC):  A61K 38/07(2006.01) A61P 17/02(2006.01) C12Q 1/37(2006.01) A61K 31/132(2006.01) A61K 9/00(2006.01) G01N 33/68(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/07; A61P 17/02; C12Q 1/37; G01N 2333/96466; G01N 33/573; G01N 2800/20; A61K 31/4184; A61K 31/405; A61K 31/192; A61K 31/603; A61K 31/436 (86) International application number: PCT/SG2024/050780 (87) International publication number: WO 2025/127999 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 SG 10202303497Y (71) Applicants: Agency for Science, Technology And Research Singapore 138632 (SG) Nanyang Technological University Singapore 639798 (SG)

(72) Inventors: BECKER, David Lawrence Singapore (SRIS), 11 Mandalay Road 17-01 Singapore 308232 (SG) VARDY, Leah Karen Anne Singapore 138648 (SG) SHI, Meng Singapore 138648 (SG) (74) Representative: Studio Torta S.p.A.  Via Viotti, 9 10121 Torino 10121 Torino (IT)