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(11)

EP 4 823 597 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24903141.0 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) C07K 14/705(2006.01) C12N 15/09(2006.01) A61P 37/06(2006.01) A61K 39/395(2006.01) C07K 19/00(2006.01) C12N 15/62(2006.01) A61P 21/04(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/395; A61P 21/04; A61P 37/06; C07K 14/70571; C07K 2319/30; C07K 2319/02; C07K 2317/52; C07K 2317/526; C07K 2317/71; C07K 16/286; C07K 16/00; A61K 38/00 (86) International application number: PCT/IL2024/051184 (87) International publication number: WO 2025/126216 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609424 P (71) Applicant: Canopy Immuno-Therapeutics Ltd. 3087500 Moshav Megadim (IL)	(72) Inventors: OVED, Kfir 3087500 Moshav Megadim, Hof HaCarmel (IL) DENKBERG, Galit 3600100 Nofit (IL) REEF, Sharon 4298401 Tsukei Yam (IL) PINZUR, Yelena 3446437 Haifa (IL) ARMAN ZELMAN, Inbar 3680304 Nesher (IL) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)