(19)

(11)

EP 4 823 598 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904741.6 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  A61K 38/20(2006.01) A61P 35/00(2006.01) C07K 14/52(2006.01) C12N 15/62(2006.01) C07K 19/00(2006.01) A61P 31/00(2006.01) A61P 37/00(2006.01) C07K 16/28(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/00; A61P 35/00; A61P 37/00; C07K 14/52; C07K 2319/74; C07K 2319/75; C07K 2319/30; C07K 14/54; C07K 14/7155; A61K 38/00 (86) International application number: PCT/US2024/059408 (87) International publication number: WO 2025/128590 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608660 P (71) Applicant: The Board of Trustees of the Leland Stanford Junior University Stanford, CA 94305-2038 (US)	(72) Inventors: GARCIA, Kenan Christopher Menlo Park, California 94025 (US) RODRIGUEZ, Grayson Fayetteville, North Carolina 28314 (US) SU, Leon Lih-Ren Mountain View, California 94040 (US) ABHIRAMAN, Gita Chu Stanford, California 94305 (US) TAO, Pingdong Redwood City, California 94063 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)