(19)

(11)

EP 4 823 599 A2

(12)

(88) Date of publication A3: 17.07.2025 (43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24841349.4 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  A61K 38/26(2006.01) A61P 3/00(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/26; A61P 3/00; C07K 16/2809; C07K 2317/75; C07K 2317/21; A61K 39/395; A61K 2039/543   C-Sets: A61K 38/26, A61K 2300/00; A61K 39/395, A61K 2300/00; (86) International application number: PCT/US2024/060080 (87) International publication number: WO 2025/129029 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610355 P 25.10.2024 US 202463712058 P (71) Applicants: Tiziana Life Sciences PLC London Greater London SW1Y 4LB (GB) The Brigham & Women's Hospital, Inc. Boston, Massachusetts 02115 (US)

(72) Inventors: CLEMENTI, William A. London Greater London SW1Y 4LB (GB) WEINER, Howard L. Brookline, Massachusetts 02445 (US) BOULENOUAR, Selma Boston, Massachusetts 02115 (US) ELRIFI, Ivor R. London Greater London SW1Y 4LB (GB) CERRONE, Gabriele London Greater London SW1Y 4LB (GB) (74) Representative: Abel & Imray LLP  Westpoint Building James Street West Bath BA1 2DA Bath BA1 2DA (GB)