(19)

(11)

EP 4 823 600 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24828040.6 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  A61K 38/45(2006.01) A61P 35/00(2006.01) C12N 15/00(2006.01) A61K 38/43(2006.01) C12N 9/12(2006.01) C12N 15/52(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/43; A61P 35/00; C12N 15/52; C12Y 207/11001; C12N 9/12; A61K 38/45 (86) International application number: PCT/EP2024/085775 (87) International publication number: WO 2025/125372 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 EP 23215683 (71) Applicant: Johann-Wolfgang-Goethe-Universität Frankfurt am Main 60323 Frankfurt am Main (DE)	(72) Inventors: STREBHARDT, Klaus 61462 Königstein i. Ts. (DE) RAAB, Monika 63549 Ronneburg (DE) SANHAJI, Mourad 60438 Frankfurt am Main (DE) BECKER, Sven 60318 Frankfurt am Main (DE) (74) Representative: Kuttenkeuler, David  SKM-IP PartGmbB Oberanger 45 80331 München 80331 München (DE)