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EP 4 823 604 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904803.4 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  A61K 39/02(2006.01) A61K 40/10(2025.01) A61K 40/13(2025.01) C07K 16/12(2026.01) (52) Cooperative Patent Classification (CPC): A61K 2039/55505; A61P 37/04; A61K 2039/521; A61K 2039/55544; A61K 2039/55566; A61K 2039/55522; A61K 2039/552; A61K 2039/6081; A61K 2039/55555; A61K 2039/55577; A61P 1/14; A61P 1/00; A61K 2039/575; A61K 2039/70; A61K 39/0001 (86) International application number: PCT/US2024/059570 (87) International publication number: WO 2025/128700 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608497 P 10.05.2024 US 202463645276 P (71) Applicant: Arkea Bio Corp. Charlestown, MA 02129 (US)

(72) Inventors: HSU, Alexander Belmont, MA 02478 (US) TABANDEH, Sara Cambridge, MA 02138 (US) DUNN, Matthew Charlestown, MA 02129 (US) ARCIERO, Brigid Charlestown, MA 02129 (US) SOUTH, Colin Charlestown, MA 02129 (US) ADOLFSEN, Kristin Charlestown, MA 02129 (US) BICKMEIER, Jeff Charlestown, MA 02129 (US) SULLIVAN, John Charlestown, MA 02129 (US) KIMLER, Sara Charlestown, MA 02129 (US) FITCH, Lauren Charlestown, MA 02129 (US) KOOS, Joseph Charlestown, MA 02129 (US) HOLLAND, Laura Charlestown, MA 02129 (US) FALK, Taylor Charlestown, MA 02129 (US) SPOONAMORE, James Charlestown, MA 02129 (US) RADULOVIC, Zeljko Charlestown, MA 02129 (US) ALLEN, Caitlin Charlestown, MA 02129 (US) LI, Anna Charlestown, MA 02129 (US) KEARNEY, Frederick, Richard Walpole, MA 02081 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)