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(11)

EP 4 823 605 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905071.7 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  A61K 39/04(2006.01) C07K 14/35(2006.01) A61K 9/51(2006.01) A61P 37/04(2006.01) C12N 15/85(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/04; C07K 14/35; A61P 37/04; C12N 15/85; A61K 9/5123; A61K 2039/53; A61K 2039/55555; A61K 2039/572; A61K 2039/545; A61K 2039/70 (86) International application number: PCT/US2024/060348 (87) International publication number: WO 2025/129174 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610211 P (71) Applicant: Beth Israel Deaconess Medical Center, Inc. Boston, MA 02215 (US)	(72) Inventors: BAROUCH, Dan H. Newton, MA 02461 (US) VIDAL, Samuel J. Boston, MA 02115 (US) (74) Representative: Duncombe, Jessica et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)