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(11)

EP 4 823 606 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905077.4 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  A61K 39/08(2006.01) C12N 15/63(2006.01) C07K 14/33(2006.01) A61P 31/04(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/33; A61K 39/08; A61P 31/04; C12N 15/67; A61K 2039/53; A61K 2039/55555; A61K 2039/70; A61K 2039/575; A61K 2039/55505; A61K 2039/55533 (86) International application number: PCT/US2024/060394 (87) International publication number: WO 2025/129186 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610388 P (71) Applicants: The Trustees of the University of Pennsylvania Philadelphia, PA 19104 (US) The Children's Hospital of Philadelphia Philadelphia, PA 19104 (US)

(72) Inventors: ALAMEH, Mohamad Philadelphia, PA 19104 (US) ZACKULAR, Joseph Philadelphia, PA 19104 (US) WEISSMAN, Drew Philadelphia, PA 19147 (US) SEMON, Alexa Philadelphia, PA 19146 (US) (74) Representative: Leonard, Thomas Charles et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)