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(11)

EP 4 823 609 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904887.7 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) C07K 14/005(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/12; C07K 14/005; A61P 31/14; C12N 2760/10022; C12N 2760/10034; A61K 2039/54; A61K 2039/55511; A61K 2039/55566; A61K 2039/545; A61K 2039/575 (86) International application number: PCT/US2024/059824 (87) International publication number: WO 2025/128854 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363608980 P 12.09.2024 US 202463693882 P (71) Applicants: The Methodist Hospital Houston, TX 77030 (US) Board of Regents, The University System of Texas Austin, TX 78701 (US)

(72) Inventors: MCLELLAN, Jason, Scott Austin, Texas 78701 (US) GOLLIHAR, JR., Jimmy Dale Houston, Texas 77006 (US) BOUTZ, Daniel, Robert Austin, Texas 78729 (US) SHROFF, Raghav Eugene, Oregon 97401 (US) KAR, Shaunak Houston, Texas 77021 (US) SEGALL-SHAPIRO, Thomas Hale Houston, Texas 77030 (US) HORTON, Andrew Pitchford Houston, Texas 77004 (US) (74) Representative: Studio Torta S.p.A.  Via Viotti, 9 10121 Torino 10121 Torino (IT)